For U.S. Residents Only Synvisc-One

Living with knee pain? It's time to do something about it.

Osteoarthritis (OA) knee pain can be frustrating and unpredictable, but ignoring it will not make it go away. Talking to your doctor is the best way to start exploring your options. When you do, keep the following in mind.

The pain affects everyone differently

An X-ray can show your grade or stage of knee osteoarthritis, but your level of pain isn’t necessarily connected to it. Your osteoarthritis could be mild with a great deal of pain or severe with little pain. Your doctor is relying on you to give a clear description of how your knee feels.

  1. Do you plan around your knee pain?
    Getting older is no excuse. You shouldn't have to give things up due to pain.

  2. Is your knee pain keeping you from exercising?
    A lack of activity can lead to even more knee pain.

  3. Are you current treatments falling short?
    If you're still in pain, talk to your doctor about trying something different.

It's caused by more than just cartilage loss

In knees with osteoarthritis, the cartilage protecting the ends of the bones gradually deteriorates, joint fluid loses its shock-absorbing qualities and bones may begin to rub against each other — all of which may cause the knee pain you’re feeling.

Your doctor is counting on you to direct your treatment

Only you know how much pain you’re in. Give your doctor a clear description of the pain and let him or her know that you’re ready to discuss other treatment options. Remember, being honest isn’t complaining. It’s about finding the relief you deserve.


Synvisc-One is a different way to treat osteoarthritis knee pain

Synvisc-One® (hylan G-F 20) is made from a natural substance that lubricates and cushions your knee, and can provide up to six months of osteoarthritis knee pain relief with just one injection. 

Find a Synvisc-One
doctor near you.

What does my doctor need to know about my knee?

Indication

Synvisc-One® (hylan G-F 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information for Synvisc-One

Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Allergic reactions, some which can be potentially severe, have been reported during the use of Synvisc-One. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, and should be used with caution when there is swelling of the legs due to problems with venous stasis or lymphatic drainage.

Synvisc-One is only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds – such as feathers, eggs or poultry – or if your leg is swollen or infected.

Synvisc-One has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.

Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after Synvisc-One include (<2% each): pain, swelling, heat, redness, and/or fluid build-up in or around the knee. Tell your doctor if you experience any side effects after treatment with Synvisc-One.

 

View the Complete Prescribing Information for Synvisc-One

Indication

SYNVISC® (hylan G-F 20) is used to relieve knee pain due to osteoarthritis (OA). It is for patients who do not get enough relief from simple painkillers such as acetaminophen, or from exercise and physical therapy.

Important Safety Information for SYNVISC

Before trying SYNVISC, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Serious allergic reactions have been reported. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

SYNVISC is only for injection into the knee, performed by a doctor or other qualified health care professional. SYNVISC has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds - such as feathers, eggs or poultry - or if your leg is swollen or infected.

SYNVISC has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after SYNVISC include pain, swelling, heat, redness, and/or fluid buildup in or around the knee. These reactions were generally mild and did not last long, but in rare occasions these side effects were more severe. The most commonly occurring adverse events outside of the injected knee were rash, fever, nausea, and headache.

View the Complete Prescribing Information for SYNVISC

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Important Safety Information: SYNVISC and Synvisc-One are contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the target knee.