For U.S. Residents Only Synvisc-One

Step, stretch & flex your way to less knee pain and more mobility.

A Program that Produced Positive Results

Our 3-Step Knee Exercise Program features a combination of exercises used in a workout that produced positive results in 38 patients in a Tufts University study1 — involving a 16-week, home-based exercise program for men and women over 50 with knee osteoarthritis.

The study results were encouraging:

  • A 36% reduction in the amount of pain
  • A 38% increase in resuming daily activities
  • An increase in overall strength and feelings of accomplishment and well-being for all participants

About the Exercises

The 3-Step Knee Exercise Program involves three kinds of exercise that are very important for joint health:

  • Aerobic Exercise — Good for warming up your muscles and joints before your routine, getting your heart rate up and helping to improve your overall fitness level.
  • Flexibility Training — Also known as stretching, these exercises help relieve stiff joints and improve your range of motion. Muscles work best when they are at their optimum length, also improving mobility.
  • Strength Training — Muscles not only help you move, they also act as shock absorbers. The stronger the muscles around the hip and knee, the better the shock absorption and stability — meaning less strain (and pain) on the joint.

About the Study

Dr. Nelson and her team conducted the study with 46 men and women over 50 who already had moderate to severe osteoarthritis. The participants had pain almost every day of the week, and many of them had swollen, red knees that disrupted their active lives.

The study featured a home-based, progressive training program. It included a series of strength, flexibility and isotonic exercises — continuous, sustained movement of the arms and legs (e.g. aerobic exercises) aimed at improving cardio function — to help reinforce the muscles around the knee and relieve joint pressure, pain and irritation.

PLEASE NOTE: The exercises and videos are presented are for informational purposes only and are not meant to take the place of the advice of your doctor. By providing you with this information, Sanofi is not endorsing its content. You should consult with your doctor before starting any new health regimen.

Reference
1. Baker, Kristin R., Nelson, Miriam E., et al. “The Efficacy of Home Based Progressive Strength Training in Older Adults with Knee Osteoarthritis: A Randomized Controlled Trial.” The Journal of Rheumatology. 2001; 28:7.

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Indication

Synvisc-One® (hylan G-F 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information for Synvisc-One

Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Allergic reactions, some which can be potentially severe, have been reported during the use of Synvisc-One. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, and should be used with caution when there is swelling of the legs due to problems with venous stasis or lymphatic drainage.

Synvisc-One is only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds – such as feathers, eggs or poultry – or if your leg is swollen or infected.

Synvisc-One has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.

Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after Synvisc-One include (<2% each): pain, swelling, heat, redness, and/or fluid build-up in or around the knee. Tell your doctor if you experience any side effects after treatment with Synvisc-One.

 

View the Complete Prescribing Information for Synvisc-One

 

Indication

SYNVISC® (hylan G-F 20) is used to relieve knee pain due to osteoarthritis (OA). It is for patients who do not get enough relief from simple painkillers such as acetaminophen, or from exercise and physical therapy.

Important Safety Information for SYNVISC

Before trying SYNVISC, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Serious allergic reactions have been reported. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

SYNVISC is only for injection into the knee, performed by a doctor or other qualified health care professional. SYNVISC has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds - such as feathers, eggs or poultry - or if your leg is swollen or infected.

SYNVISC has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after SYNVISC include pain, swelling, heat, redness, and/or fluid buildup in or around the knee. These reactions were generally mild and did not last long, but in rare occasions these side effects were more severe. The most commonly occurring adverse events outside of the injected knee were rash, fever, nausea, and headache.

View the Complete Prescribing Information for SYNVISC

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Important Safety Information: SYNVISC and Synvisc-One are contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the target knee.