For U.S. Residents Only Synvisc-One

Maintain a healthy weight to help reduce strain (and pain) in your knees.

Weighing the Benefits of Dropping a Few Pounds

Gaining weight puts a lot of extra stress and strain on your knees, which must bear the brunt of those excess pounds. The added pressure increases wear and tear, contributing to osteoarthritis. On the flip side, losing weight can help you take a load off, literally. One study (Arthritis and Rheumatism, July 2005) found that every lost pound subtracts four pounds of pressure from the knees for each step taken. In practical terms, losing just 10 pounds means that each knee is subjected to 48,000 fewer pounds of pressure for every mile walked.

Small losses, big gains

The implication: Even a fairly small weight loss can make a big difference for overweight people with knee osteoarthritis. Two other studies bear out this assumption.

Study 1. The larger of the studies was the Arthritis, Diet, and Activity Promotion Trial (ADAPT; Arthritis and Rheumatism, May 2004), conducted by researchers at Wake Forest University. It included 316 adults ages 60 and older who were overweight and had knee osteoarthritis. These individuals were randomly assigned to either a treatment group (diet, exercise or diet-plus-exercise) or a control group that simply got general information about a healthy lifestyle.

The best results were achieved by those in the diet-plus-exercise group, who lost about 6 percent of their body weight over an 18-month period. For someone starting out at 200 pounds, that would mean losing just 12 pounds over the course of a year and a half. This modest weight loss combined with moderate exercise led to the greatest overall improvements in pain, physical function and the ability to get around.

Study 2. Results from a second study, conducted by researchers at Johns Hopkins University, were reported at the 2006 annual meeting of the American College of Rheumatology. This study included 30 overweight adults with knee osteoarthritis who took part in a weight loss program. The program consisted of 16 weekly classes on diet, exercise and lifestyle change. After the classes ended, the group got back together every three months for a year to talk about keeping the weight off.

At the end of the 16-week class period, participants had lost an average of 15 pounds. They regained some of that weight over the next year, but they kept off more than half of it, on average. Weight loss was associated with lasting reductions in pain. And a positive cycle seemed to ensue. Decreased pain, in turn, was associated with better weight maintenance, probably because being in less pain made it easier to stay motivated and active.

Lose to win

To lose weight, you need to take in fewer calories through food than you burn off by exercise. You can do that by eating less or exercising more — but the best results are often achieved with a combination of both. Since a pound of fat is about 3,500 calories, you can lose that amount in a week by aiming for a deficit of 500 calories a day. For instance, you might aim to burn an extra 200 calories through exercise and cut another 300 calories from your diet.

The bottom line

If you’re overweight, dropping a few excess pounds can reduce the wear and tear on your knees. Beyond that, losing just 5 percent to 10 percent of your body weight can lower your odds of developing heart disease or having a stroke. And when combined with exercising at a moderate level of effort for 30 minutes a day, 5 days a week, it can help prevent or delay the onset of type 2 diabetes. So lose a few pounds, and you may gain better health.

PLEASE NOTE: The studies and their findings that are presented in this article are for informational purposes only and are not meant to take the place of the advice of your doctor. By providing you with this information, Sanofi Biosurgery is not endorsing its content nor does it represent that the information is necessarily appropriate for you. You should consult with your doctor before starting any new health or exercise regimen.

References

“Osteoarthritis: What causes it?” Arthritis Foundation. Available at: http://www.arthritis.org/disease-center.php?disease_id=32&df=causes. Accessed September 6, 2011.

“Weight Loss Reduces Knee-Joint Loads in Overweight and Obese Older Adults with Knee Osteoarthritis.” S.P. Messier et al. Arthritis and Rheumatism. July 2005, vol. 52, no. 7, pp. 2026-2032.

“Exercise and Dietary Weight Loss in Overweight and Obese Older Adults with Knee Osteoarthritis: The Arthritis, Diet, and Activity Promotion Trial.” S.P. Messier et al. Arthritis and Rheumatism. May 2004, vol. 50, no. 5, pp. 1501-1510.

“Nutrition for Weight Loss: What it Takes to Lose Weight.” American Academy of Family Physicians. Available at: http://familydoctor.org/online/famdocen/home/healthy/food/improve/795.printerview.html. Accessed September 6, 2011.

“Do You Know the Health Risks of Being Overweight?” Weight-Control Information Network. Available at: http://win.niddk.nih.gov/publications/health_risks.htm. Accessed September 6, 2011.

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Indication

Synvisc-One® (hylan G-F 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information for Synvisc-One

Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Allergic reactions, some which can be potentially severe, have been reported during the use of Synvisc-One. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, and should be used with caution when there is swelling of the legs due to problems with venous stasis or lymphatic drainage.

Synvisc-One is only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds – such as feathers, eggs or poultry – or if your leg is swollen or infected.

Synvisc-One has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.

Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after Synvisc-One include (<2% each): pain, swelling, heat, redness, and/or fluid build-up in or around the knee. Tell your doctor if you experience any side effects after treatment with Synvisc-One.

 

View the Complete Prescribing Information for Synvisc-One

 

Indication

SYNVISC® (hylan G-F 20) is used to relieve knee pain due to osteoarthritis (OA). It is for patients who do not get enough relief from simple painkillers such as acetaminophen, or from exercise and physical therapy.

Important Safety Information for SYNVISC

Before trying SYNVISC, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Serious allergic reactions have been reported. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

SYNVISC is only for injection into the knee, performed by a doctor or other qualified health care professional. SYNVISC has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds - such as feathers, eggs or poultry - or if your leg is swollen or infected.

SYNVISC has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after SYNVISC include pain, swelling, heat, redness, and/or fluid buildup in or around the knee. These reactions were generally mild and did not last long, but in rare occasions these side effects were more severe. The most commonly occurring adverse events outside of the injected knee were rash, fever, nausea, and headache.

View the Complete Prescribing Information for SYNVISC

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Important Safety Information: SYNVISC and Synvisc-One are contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the target knee.