For U.S. Residents Only Synvisc-One

Distributors Outside the US

To learn how to contact a SYNVISC distributor outside the United States, select the country name.


Argentina

Genzyme de Argentina S.A.
Fondo de la Legua 161
B1609JEB Boulogne,
Provincia de Buenos Aires
Argentina
Tel: +54 11 4708-6900
Fax: +54 11 4700-8111
http://www.genzyme.com.ar

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Australia

Genzyme Australasia Pty Ltd
Norwest Quay Level 1, Building C,
12-24 Talavera Road
North Ryde NSW 2113
Australia
Tel: +61-2-9978-3900
Fax: +61-2-9889-3900
http://www.genzyme.com.au

Mailing Address:
PO Box 282
North Ryde B/C NSW 1670
Australia

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Austria

Genzyme Austria GmbH
Franz-Klein-Gasse 5
1190 Vienna
Austria
Tel: +43 (0) 1-774-6538
Fax: +43 (0) 1-774-65389

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Belgium

Genzyme Belgium NV/SA
Ikaroslaan 53
B-1930 Zaventem
Belgium
Tel: +32 2714 1711
Fax: +32 2714 1707
http://www.genzyme.be

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Bolivia

Genzyme de Argentina S.A.
Fondo de la Legua 161
B1609JEB Boulogne,
Provincia de Buenos Aires
Argentina
Tel: +54 11 4708-6900
Fax: +54 11 4700-8111
http://www.genzyme-latinoamerica.com/

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Brazil

Genzyme do Brasil Ltda
Rua Padre Chico, 224
CEP 05008-010
São Paulo - SP, Brasil
Tel: +55 11 3874 9950
Fax: +55 11 3874-9952
Customer Services: 0800 77 123 73
http://www.genzyme.com.br

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Bulgaria

Genzyme CEE GmbH
Central and Eastern Europe
Bleicherstrasse 10
78467 Konstanz
Germany
Tel: +49 (0) 7531 45727 0
Fax: +49 (0) 7531 45727 99

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Canada

Genzyme Biosurgery
Canadian Office
2700 Matheson Blvd. East
West Tower, Suite 800
Mississauga, Ontario L4w 4v9
Canada
Tel: 905-625-0011
Fax: 905-625-7811
Toll Free: 877-220-8918
http://www.genzyme.ca

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Central America & The Carribbean

Farmacéutica S.A.
Anillo Periferico 30-31 zona11
Guatemala City
Guatemala
Central America
Apdo. Postal 1115
Tel: +502-2422-8400
Fax: +502-2422-8401

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Chile

Novartis Chile S.A.
de Correo 9993
Santiago de Chile
Chile
Tel: +562-350-0233
Fax: +562-239-3154

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China

Genzyme China - Beijing Office
Tower-3 of China Central Place Office Building, Unit 1003B
No. 77, Jianguo Road, Chaoyang District
Beijing, China 100025
Tel: 86-10-5904-7000
Fax: 86-10-5904-7199

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Colombia

Genzyme de Colombia S.A.
Calle 93b # 17-25
Bogota, Colombia
Teléfono 57-1 6216600
Fax: 57-1 6216677.
http://www.genzyme.com.co

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Croatia

Genzyme CEE GmbH Croatia
Gracanska cesta 127/II
1 00 00 Zagreb, Croatia
Tel: +38514618333
Fax: +385 14618333

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Czech Republic

Genzyme Europe BV
organizacní složka
Na Žertvách 2247/29
180 00 Prague 8
Czech Republic
Tel: +420 227 133 665
Fax: +420 227 133 660

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Ecuador

Novartis De Ecuador
Av. colon 1468 y de Octubre
Edif. Solamar Piso 8 - Quito Ecuador
Tel: +5932-222-7620

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Estonia

Genzyme Polska Sp. z o.o.
Al. Stanów Zjednoczonych 61 A
04-028 Warsaw
Poland
Tel: +48 22 516 24 30 or 32
Fax: +48 22 516 24 31

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France

Genzyme s.a.s.
33/35 Boulevard de la Paix
d'Activité du Bel Air
78105 Saint Germain en Laye Cedex
France
Tel : +33 1 30 87 25 25
Fax : +33 1 30 87 26 26
http://www.genzyme.fr

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Germany

Genzyme GmbH
Siemensstraße 5b
63263 Neu-Isenburg
Deutschland
Tel: +49 (0) 6102 3674 – 0
Fax: +49 (0) 6102 3674 – 100
Information for German Patients

Information for German Health Care Professionals (DocCheck password required)

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Greece

Genzyme Hellas LLC
Vouliagmenis Ave.
164 52, Argyroupoli,
Athens
Greece
Tel: +0030 210 994 9270
Fax: +0030 210 994 4062

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Guatemala

Novartis Farmacéutica S.A.
Anillo Periferico 30-31 zona11
Guatemala City
Guatemala
Central America
Apdo. Postal 1115
Tel: +502-2-4228400
Fax: +502-2-4228401

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Hong Kong

Genzyme Asia Limited
Unit 1904-05, Jubilee Centre
46 Gloucester Road
Wanchai, Hong Kong
Tel: 852-2810-1613
Fax: 852-2810-1667
http://www.genzyme.com.hk

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Hungary

Genzyme Europe B.V. Képviselet
1124 Budapest
Apor Vilmos tér 25-26
Hungary
Tel: +36 1 310 7440
Fax: +36 1 310 7441

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India

Genzyme India Pvt. Limited
1st Floor, Technopolis
Golf Course Road, Sector 54
Gurgaon – 122 001
India
Tel: +91 124 4528300
Fax: +91 124 4528400

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Ireland

Genzyme Ltd
4620 Kingsgate
Cascade Way
Oxford Business Park South
Oxford
OX4 2SU
UK
Tel: +44-1865-405200
Fax: +44-1865-774172

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Israel

Genzyme Israel Ltd
Beit-Hapaamon, Hataas Street 20
Kfar-Saba-Industrial Zone 44111
Israel
Tel: +972-9-7-666640
Fax: +972-9-7-666631
Israel
http://www.genzyme.co.il/

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Italy

Genzyme Biosurgery Italy
via Scaglia est 144
41100 Modena
Italy
Tel: +39-059-349813/11
Fax: +39-059-348042

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Korea

Genzyme Korea
#803, Wscs Bldg.
Hannam-1-Dong
Yongsan-Ku
Seoul 140-211
Korea
Tel: +82-2-790-814/8817
: +82-2-749-8812
www.genzyme.com.hk

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Latvia

Genzyme Polska Sp. z o.o.
Al. Stanów Zjednoczonych 61 A
04-028 Warsaw
Poland
Tel: +48 22 516 24 30 or 32
Fax: +48 22 516 24 31

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Liechtenstein

Genzyme GmbH
Bahnhofstrasse 21
Postfach
CH-6301 Zug
Switzerland
Tel: +41-41-727-8020
Fax: +41-41-727-8029

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Lithuania

Genzyme Polska Sp. z o.o
al. Stanow Zjednoczonych 61a
04-028 Warsaw, Poland
Tel: +48 22 516 24 30
Fax: +48 22 51624 31

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Luxembourg

Genzyme Belgium nv/ sa
Ikaroslaan 33 B-1930 Zaventem
Belgium
Tel: +32-2-714-1711
Fax: +32-2-714-1707

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Malaysia

Genzyme Malaysia Sdn. Bhd.
Unit E305, East Wing Metropolitan Square,
Jalan PJU 8/1, Bandar Damansara Perdana,
47820 Petaling Jaya, Selangor,
MALAYSIA
Tel: +60-3-7662-3327
Fax: +60-3-7662-3329

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Mexico

Genzyme México S. de R.L. de C.V.
Paseo de la Reforma 505 Piso 49
Col. Cuauhtémoc
06500 México, D.F.
Tel.: +52 55 5241 0600
Fax +52 55 5241 0659
Lada: 01 800 0436 0963

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The Netherlands

Genzyme Nederlands
Gooimeer 10
1411 DD Naarden
Tel: +31-35-699-1200
Fax: +31-35-694-32
www.genzyme.nl

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New Zealand

Genzyme Australasia Pty Ltd
Norwest Quay Level 1, Building C,
12-24 Talavera Road
North Ryde NSW 2113
Australia
Tel: +61-2-9978-3900
Fax: +61-2-9889-3900
www.genzyme.com.au

Mailing Address:
PO Box 282
North Ryde B/C NSW 1670

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Nicaragua

Novartis Farmacéutica S.A.
Periferico 30-31 zona11
Guatemala City, Guatemala
Central America
Apdo. Postal 1115
Tel: +502-473-7334
Fax: +502-473-8357

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Norway

Genzyme A/S
Islands Brygge 57 st tv
DK-2300 Copenhagen S
Denmark
Phone: +45-32 712 600
Fax: +45-32 712 601

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Panama

Novartis Farmacéutica S.A.
Anillo Periferico 30-31 zona 11
Guatemala City, Guatemala
Central America
Apdo. Postal 1115
Tel: +502-473-7334
Fax: +502-473-8357

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Paraguay

Genzyme de Argentina S.A.
Fondo de la Legua 161
B1609JEB Boulogne,
Provincia de Buenos Aires
Argentina
Tel: +54 11 4708-6900
Fax: +54 11 4700-8111
www.genzyme-latinoamerica.com/

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Peru

Novartis Biosciencias Peru S.A.
Casilla Postal 10376
Lima 100
Peru
Contact: Carlos Silva
Email: carlos.silva@novartis.com
Tel: +51-1494-2788
Fax: +51-1494-2673

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Philippines

Globo Asiatico Enterprises, Inc.
JDK Building
127 Maginhawa Street
Teachers Village-East, Quezon City
1101 Philippines
Tel: 63 2 441-0253 to 55
Fax: 63 2 441-0282

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Poland

Genzyme
Polska Sp. z o.o
al. Stanow Zjednoczonych 61a
04-028 Warsaw, Poland
Tel: +48 22 516 24 30
Fax +48 22 516 24 31

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Portugal

Genzyme Portugal
Taguspark
Edifício Ciência II, 2° Sala 2 D 2740-120 Porto Salvo
Portugal
Tel: +351 21 422 0100
Fax: +351 21 422 0110
http://www.genzyme.com.pt/

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Romania

Genzyme CEE GmbH
Central and Eastern Europe
Bleicherstrasse 10
78467 Konstanz
Germany
Tel: +49 (0) 7531 45727 0
Fax: +49 (0) 7531 45727 99

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Russia

Genzyme GmbH Russia
Hotel Orlionok Kosygina Street 15
119334 Moscow
Russia
Tel: +7 (0)95 939 85 29
Fax: +7 (0)95 939 85 29

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Singapore

Genzyme Singapore Pte. Ltd
#21-01 Suntec Tower 4
6 Temasek Boulevard
Singapore 038986
Tel: +65 6337 9707
Fax: +65 6337 9709

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Slovak Republic

Genzyme Europe BV
organizacní složka
Na Žertvách 2247/29
180 00 Prague 8
Czech Republic
Tel: +420 227 133 665
Fax: +420 227 133 660

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Slovenia

Genzyme CEE
GmbH Croatia
Gracanska cesta 127/II
1 00 00 Zagreb, Croatia
Tel: +385 14618333
Fax: +385 14618333

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South Africa

SA Biomedical Pty Ltd
1 Martha Street, Marlboro Gardens
Eastgate Extension, Sandton
Johannesburg, South Africa
Tel: +27-11-531-5000
Fax: +27-11-4444-6047

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Spain

Genzyme Biosurgery Spain
Damián Sánchez López, 3
28700 S.S. de los reyes
Madrid
Spain
Tel: +34-916-591-670
Fax: +34-916-596-852

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Sweden

Genzyme A/S
Islands Brygge 57 st tv
DK-2300 Copenhagen S
Denmark
Phone: +45-32 712 600
Fax: +45-32 712 601

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Switzerland

Genzyme GmbH
Bahnhofstrasse 21
Postfach
CH-6301 Zug
Switzerland
Tel: +41-41-727-8020
Fax: +41-41-727-8029

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Taiwan

Giddi Pharma Co., Ltd.
No. 369, Sihwei Rd, Taipei, 106, Taiwan, ROC
Tel: + 886-2-25251476
Fax: + 886-2-25251477

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Thailand

Berli Jucker Public Company Limited
Berli Jucker House, 99 Soi Rubia
Sukhumvit 42 Road
Phrakanong, Klongtoey
Bangkok 10110, Thailand
Tel: +66-2367-1095/2367/1243
Fax: +66-2712-2240/2381/4551

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Trinidad and Tobago

Novartis Farmacéutica S.A.
Periferico 30-31 zona11
Guatemala City, Guatemala
Central America
Apdo. Postal 1115
Tel: +502-473-7334
Fax: +502-473-8357

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Turkey

Genzyme Turkey Ltd.
Suleyman Seba Caddesi
BJK Plaza A98 Besiktas
Istanbul 34357
Turkey
Tel: + 90 (212) 327 8760
Fax: + 90 (212) 327 8763

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Ukraine

Genzyme CEE GmbH
Central and Eastern Europe
Bleicherstrasse 10
78467 Konstanz
Germany
Tel: +49 (0) 7531 45727 0
Fax: +49 (0) 7531 45727 99

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United Kingdom

Genzyme Ltd
4620 Kingsgate
Cascade Way
Oxford Business Park South
Oxford
OX4 2SU
United Kingdom
Tel: +44-1865-405200
Fax: +44-1865-774172
Genzyme UK information for Patients

Genzyme UK information for Health Care Professionals
(DocCheck password required)

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United States

Genzyme Biosurgery,
a division of Genzyme Corporation
55 Cambridge Parkway
Cambridge, MA 02142
Information for US Patients

Information for US Health Care Professionals
Tel: 1-888-3-SYNVISC (1-888-379-6847)

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Uruguay

Novartis Uruguay S.A.
Cebollati 1470 piso 2
Montevideo CP 11200
Uruguay
Contact: Elsa Orosa
Tel: +598-2-4133694
Fax: +598-2-4133245

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Venezuela

Novartis de Venezuela S.A.
3ra. Transversal Los Ruices
Ed. Novartis
Aptdo. 68097, Caracas 1062-A,
Venezuela
Tel: +58-2-239-4011
Fax: +58-2-239-1068

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Indication

Synvisc-One® (hylan G-F 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information for Synvisc-One

Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Allergic reactions, some which can be potentially severe, have been reported during the use of Synvisc-One. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, and should be used with caution when there is swelling of the legs due to problems with venous stasis or lymphatic drainage.

Synvisc-One is only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds – such as feathers, eggs or poultry – or if your leg is swollen or infected.

Synvisc-One has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.

Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after Synvisc-One include (<2% each): pain, swelling, heat, redness, and/or fluid build-up in or around the knee. Tell your doctor if you experience any side effects after treatment with Synvisc-One.

 

View the Complete Prescribing Information for Synvisc-One

 

Indication

SYNVISC® (hylan G-F 20) is used to relieve knee pain due to osteoarthritis (OA). It is for patients who do not get enough relief from simple painkillers such as acetaminophen, or from exercise and physical therapy.

Important Safety Information for SYNVISC

Before trying SYNVISC, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Serious allergic reactions have been reported. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

SYNVISC is only for injection into the knee, performed by a doctor or other qualified health care professional. SYNVISC has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds - such as feathers, eggs or poultry - or if your leg is swollen or infected.

SYNVISC has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after SYNVISC include pain, swelling, heat, redness, and/or fluid buildup in or around the knee. These reactions were generally mild and did not last long, but in rare occasions these side effects were more severe. The most commonly occurring adverse events outside of the injected knee were rash, fever, nausea, and headache.

View the Complete Prescribing Information for SYNVISC

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Important Safety Information: SYNVISC and Synvisc-One are contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the target knee.