For U.S. Residents Only Synvisc-One

Get answers to your questions about SYNVISC.

What is SYNVISC?

SYNVISC is a viscosupplement injection that supplements the fluid in your knee to help lubricate and cushion the joint, and can provide up to six months of osteoarthritis knee pain relief with three injections.

When should I consider SYNVISC?

SYNVISC is for people with knee osteoarthritis who have not received enough pain relief from diet, exercise and over-the-counter pain medication. If you’ve tried these options and are still feeling knee pain, tell your doctor and ask if SYNVISC or Synvisc-One® (hylan G-F 20) could help.

How is SYNVISC given?

SYNVISC is typically provided by a specialist such as an orthopaedic surgeon or rheumatologist. It is injected directly into the knee over the course of three doctor visits, one week apart.

Is SYNVISC covered by insurance?

SYNVISC is covered by Medicare and most insurance plans. If you have been denied coverage click here.

What are the side effects of SYNVISC?

In studies, about 7% of patients experienced pain, swelling and/or fluid buildup around the knee. Other side effects, such as rash, have been reported rarely.

What is the procedure like?

Each injection takes a few minutes and can be done in your doctor’s office. To watch a video of a real patient’s injection with Synvisc-One, click here.

Will the injections hurt?

Your doctor will likely apply a numbing agent before your SYNVISC injections.

What happens after the injections?

It is recommended you avoid strenuous activities (for example, high-impact sports such as tennis or jogging) or prolonged weight-bearing activities for approximately 48 hours following each injection. You should consult your doctor regarding the appropriate time to resume these activities.

When will I start to feel pain relief?

Some patients may begin to feel osteoarthritis knee pain relief after the first injection, but you need to have all three injections to get the maximum benefit. Although everyone responds differently, most patients feel the greatest relief 8 to 12 weeks after the first injection.

How long will I experience knee pain relief?

Although all patients respond differently, your osteoarthritis knee pain relief can last up to six months.

Can I receive SYNVISC treatment more than once?

Yes, SYNVISC can be repeated safely. When your osteoarthritis knee pain returns, talk to your doctor to see whether SYNVISC or Synvisc-One is right for you.

Can both my knees be treated with SYNVISC?

Yes. You can receive treatment in both knees at the same time or at different times. Ask your doctor what is best for you.

What is SYNVISC made from?

The injection contains a gel-like mixture made from a substance called hyaluronan (pronounced hy-al-u-ROE-nan) that comes from chicken combs. Hyaluronan is a natural substance found in the body and is present in very high amounts in joints. The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint and is needed for the joint to work properly.

How is SYNVISC different from Synvisc-One?

SYNVISC is the same formulation as Synvisc-One. The only difference is that Synvisc-One is provided with one injection, compared to the three injections required for SYNVISC. Both treatments can provide up to six months of osteoarthritis knee pain relief.

Find a Synvisc-One
doctor near you.

Sign up for emails

with tips for managing your osteoarthritis knee pain
before or after treatment.


Click here to unsubscribe from our email communications.

Indication

Synvisc-One® (hylan G-F 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information for Synvisc-One

Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

Synvisc-One is only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds – such as feathers, eggs or poultry – or if your leg is swollen or infected.

Synvisc-One has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.

Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after Synvisc-One include (<2% each): pain, swelling, heat, redness, and/or fluid build-up in or around the knee. Tell your doctor if you experience any side effects after treatment with Synvisc-One.

View the Complete Prescribing Information for Synvisc-One (PDF)

Indication

SYNVISC® (hylan G-F 20) is used to relieve knee pain due to osteoarthritis (OA). It is for patients who do not get enough relief from simple painkillers such as acetaminophen, or from exercise and physical therapy.

Important Safety Information for SYNVISC

Before trying SYNVISC, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

SYNVISC is only for injection into the knee, performed by a doctor or other qualified health care professional. SYNVISC has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds - such as feathers, eggs or poultry - or if your leg is swollen or infected.

SYNVISC has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after SYNVISC include pain, swelling, heat, redness, and/or fluid buildup in or around the knee. These reactions were generally mild and did not last long, but in rare occasions these side effects were more severe. The most commonly occurring adverse events outside of the injected knee were rash, fever, nausea, and headache.

View the Complete Prescribing Information for SYNVISC (PDF)

-
Important Safety Information: SYNVISC and Synvisc-One are contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the target knee.