Get answers to your questions about SYNVISC.

Prior to the introduction of Synvisc-One® (hylan G-F 20), there was SYNVISC® (hylan G-F 20) — a similar product that provided up to six months of osteoarthritis knee pain relief with three injections. In the past 10 years, more then five million treatments of SYNVISC have been administered in the United States.

What is SYNVISC?

SYNVISC is a type of osteoarthritis knee pain treatment called a viscosupplement or hyaluronan injection. It lubricates and cushions your knee joint and relieves pain, which can allow you to move more freely for up to six months.

How is SYNVISC different from Synvisc-One?

SYNVISC is the same formulation as Synvisc-One. The only difference is that Synvisc-One is provided with one injection, compared to the three injections required for SYNVISC. Both treatments can provide up to six months of osteoarthritis knee pain relief.

Is the cost of SYNVISC covered by insurance?

The cost of SYNVISC varies, however the treatment is typically eligible for reimbursement by Medicare and most insurance plans. Check with your insurance plan to determine your exact benefits. If you are denied insurance coverage for your SYNVISC treatment, please contact SYNVISC ConnectionSM at 1-800-982-8292, M–F, 9am–8pm (ET).

How is SYNVISC given?

SYNVISC is injected directly into the knee over the course of three doctor visits, one week apart. It’s a simple, in-office procedure that takes just a few minutes.

What are the side effects?

Since SYNVISC is injected directly into the knee, it has fewer serious side effects than pills, which are absorbed into the bloodstream. Side effects from SYNVISC are infrequent. In studies, about 7% of patients experienced pain, swelling and/or fluid buildup around the knee. Other side effects, such as rash, have been reported rarely.

Should I reduce my activity after being treated with SYNVISC?

After each injection, you can resume normal day-to-day activities, but you should avoid any strenuous activities for about 48 hours.

When will I start to feel pain relief?

Some patients may begin to feel osteoarthritis knee pain relief after the first injection, but you need to have all three injections to get the maximum benefit. Although everyone responds differently, most patients feel the greatest relief 8 to 12 weeks after the first injection.

How long will I experience relief?

Although all patients respond differently, your osteoarthritis knee pain relief can last up to six months.

Can I receive SYNVISC more than once?

Yes, SYNVISC can be repeated safely. When your osteoarthritis knee pain returns, talk to your doctor to see whether SYNVISC or Synvisc-One is right for you.

Can both my knees be treated with SYNVISC?

Yes. You can receive treatment in both knees at the same time or at different times. Ask your doctor what is best for you.

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Indication

Synvisc-One® (hylan G-F 20) and SYNVISC® (hylan G-F 20) are indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information

Before trying Synvisc-One or SYNVISC, tell your doctor if you are allergic to products from birds — such as feathers, eggs or poultry — or if your leg is swollen or infected. Synvisc-One and SYNVISC are only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One and SYNVISC have not been tested to show pain relief in joints other than the knee. Talk to your doctor before resuming strenuous weight-bearing activities after treatment. Synvisc-One and SYNVISC have not been tested in children, pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. The side effects most commonly seen when Synvisc-One or SYNVISC is injected into the knee were pain, swelling and/or fluid buildup in or around the knee. Cases where the swelling is extensive or painful should be discussed with your doctor. Allergic reactions such as rash and hives have been reported rarely.

View the Complete Prescribing Information for Synvisc-One (PDF)
View the Complete Prescribing Information for SYNVISC (PDF)