Get up to six months of relief with just one injection.

Synvisc-One® (hylan G-F 20) is the only treatment that can provide up to six months of osteoarthritis knee pain relief with a single injection. And, since it is injected directly into the knee, Synvisc-One doesn't have the serious side effects found with many pain pills. The chart below will help you evaluate common injection therapies and learn what to expect with these treatments.

Evaluating Injection Therapies

  APPROVED
DOSING		 DURATION OF
PAIN RELIEF
(up to)
Viscosupplement Injections    
Synvisc-One® (hylan G-F 20)1 1 injection 26 weeks
SYNVISC® (hylan G-F 20)2 3 injections 26 weeks
Hyalgan® (sodium hyaluronate)3,4 5 injections 26 weeks
Supartz® (sodium hyaluronate)4,5 5 injections 26 weeks
Orthovisc® (high molecular weight hyaluronan)6,7 3-4 injections 22 weeks
Euflexxa® (1% sodium hyaluronate)4,8 3 injections 12 weeks
Steroid Injections    
Cortisone (also called corticosteroids)9,10 1 injection 2-6 weeks
NEXT: Hear from Patients Who Have Found Success with Synvisc-One
References
1. Synvisc-One Prescribing Information. Cambridge, MA: Genzyme Corp; 2010.
2. SYNVISC Prescribing Information. Cambridge, MA: Genzyme Corp; 2010.
3. Hyalgan Prescribing Information. Parsippany, NJ: Fidia Pharma USA Inc; 2011.
4. Data on file. Genzyme Corp.
5. Supartz Prescribing Information. Memphis, TN: Smith & Nephew, Inc; 2007.
6. Orthovisc Prescribing Information. Bridgewater, NJ: Ortho Biotech Products, LP; 2005.
7. Rheology of joint fluid in total knee arthroplasty patients. Mazzucco D, McKinley G, Scott RD, Spector M. J Orthop Res. 2002;20:1157-1163.
8. Euflexxa Prescribing Information. Suffern, NY: Ferring Pharmaceuticals Inc; 2009.
9. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Cochrane Database Syst Rev. 2006;(2):CD005328. doi:10.1002/14651858.CD005328.pub2.
10. Corticosteroid injections for osteoarthritis. Stitik TP, Kumar A, Foye PM. Am J Phys Med Rehabil. 2006;85(11)(suppl):S51-S65.

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A doctor's perspective

"Many of my patients are concerned about the risks of taking medications all the time. Synvisc-One may give them the ability to lessen their need for pain pills or maybe completely avoid them."

 — Dr. DiNubile, orthopaedic surgeon and sports medicine specialist

Learn more about Synvisc-One

Indication

Synvisc-One® (hylan G-F 20) and SYNVISC® (hylan G-F 20) are indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information

Before trying Synvisc-One or SYNVISC, tell your doctor if you are allergic to products from birds — such as feathers, eggs or poultry — or if your leg is swollen or infected. Synvisc-One and SYNVISC are only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One and SYNVISC have not been tested to show pain relief in joints other than the knee. Talk to your doctor before resuming strenuous weight-bearing activities after treatment. Synvisc-One and SYNVISC have not been tested in children, pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. The side effects most commonly seen when Synvisc-One or SYNVISC is injected into the knee were pain, swelling and/or fluid buildup in or around the knee. Cases where the swelling is extensive or painful should be discussed with your doctor. Allergic reactions such as rash and hives have been reported rarely.

View the Complete Prescribing Information for Synvisc-One (PDF)
View the Complete Prescribing Information for SYNVISC (PDF)