Synvisc-ONE is a different way to treat osteoarthritis knee pain.


Synvisc-One® (hylan G-F 20) is an injection that supplements the fluid in your knee to help lubricate and cushion the joint, and can provide up to six months of osteoarthritis knee pain relief.

What is Synvisc-One?

In knees with osteoarthritis, the joint fluid (called synovial fluid) can break down and not provide the cushioning your knee needs. Click the play button above to learn how Synvisc-One supplements your knee joint fluid to relieve the pain and improve your knee joint's natural shock absorbing abilities.

What is Synvisc-One made from?

The injection contains a gel-like mixture made from a substance called hyaluronan (pronounced hy-al-u-ROE-nan) that comes from chicken combs.

Hyaluronan is a natural substance found in the body and is present in very high amounts in joints. The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint and is needed for the joint to work properly.

How do I know if I’m ready for Synvisc-One?

Synvisc-One is for people with knee osteoarthritis who have not received enough pain relief from diet, exercise and over-the-counter pain medication. If you’ve tried these options and are still feeling knee pain, tell your doctor and ask if Synvisc-One could help.

How is Synvisc-One given?

Synvisc-One is a single-dose treatment that is injected directly into your knee by a doctor. To watch a video of a real patient’s injection, click here.

Who provides Synvisc-One?

Synvisc-One is usually administered by a specialist trained in treating knee osteoarthritis, such as an orthopaedic surgeon or rheumatologist.

Get a quick overview of Synvisc-One.

Watch Video