Get answers to your questions about SYNVISC.


What is SYNVISC?

SYNVISC is a viscosupplement injection that supplements the fluid in your knee to help lubricate and cushion the joint, and can provide up to six months of osteoarthritis knee pain relief with three injections.

When should I consider SYNVISC?

SYNVISC is for people with knee osteoarthritis who have not received enough pain relief from diet, exercise and over-the-counter pain medication. If you’ve tried these options and are still feeling knee pain, tell your doctor and ask if SYNVISC or Synvisc-One® (hylan G-F 20) could help.

How is SYNVISC given?

SYNVISC is typically provided by a specialist such as an orthopaedic surgeon or rheumatologist. It is injected directly into the knee over the course of three doctor visits, one week apart.

Is SYNVISC covered by insurance?

SYNVISC is covered by Medicare and most insurance plans. If you have been denied coverage click here.

What are the side effects of SYNVISC?

In studies, about 7% of patients experienced pain, swelling and/or fluid buildup around the knee. Other side effects, such as rash, have been reported rarely.

What is the procedure like?

Each injection takes a few minutes and can be done in your doctor’s office. To watch a video of a real patient’s injection with Synvisc-One, click here.

Will the injections hurt?

Your doctor will likely apply a numbing agent before your SYNVISC injections.

What happens after the injections?

It is recommended you avoid strenuous activities (for example, high-impact sports such as tennis or jogging) or prolonged weight-bearing activities for approximately 48 hours following each injection. You should consult your doctor regarding the appropriate time to resume these activities.

When will I start to feel pain relief?

Some patients may begin to feel osteoarthritis knee pain relief after the first injection, but you need to have all three injections to get the maximum benefit. Although everyone responds differently, most patients feel the greatest relief 8 to 12 weeks after the first injection.

How long will I experience knee pain relief?

Although all patients respond differently, your osteoarthritis knee pain relief can last up to six months.

Can I receive SYNVISC treatment more than once?

Yes, SYNVISC can be repeated safely. When your osteoarthritis knee pain returns, talk to your doctor to see whether SYNVISC or Synvisc-One is right for you.

Can both my knees be treated with SYNVISC?

Yes. You can receive treatment in both knees at the same time or at different times. Ask your doctor what is best for you.

What is SYNVISC made from?

The injection contains a gel-like mixture made from a substance called hyaluronan (pronounced hy-al-u-ROE-nan) that comes from chicken combs. Hyaluronan is a natural substance found in the body and is present in very high amounts in joints. The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint and is needed for the joint to work properly.

How is SYNVISC different from Synvisc-One?

SYNVISC is the same formulation as Synvisc-One. The only difference is that Synvisc-One is provided with one injection, compared to the three injections required for SYNVISC. Both treatments can provide up to six months of osteoarthritis knee pain relief.

Find a Synvisc-One doctor near you.