Find out how patients responded in a Synvisc-One medical study.


Synvisc-One® (hylan G-F 20) can provide up to six months of osteoarthritis knee pain relief with a single injection.

64 percent of patients reported pain relieft with synvisc-one

Synvisc-One Medical Study

In order to determine how well Synvisc-One reduced osteoarthritis knee pain during five common activities (walking on a flat surface, going up stairs, resting during the night, sitting or lying down, and standing upright), a medical study1 of 253 patients with knee osteoarthritis was conducted and the side effects were tracked.

Knee pain relief results with Synvisc-One

The study showed that patients who received Synvisc-One had significantly less osteoarthritis knee pain over six months and felt significantly better than the saline control group. Most patients reported knee pain relief starting at week four.

Side effects with Synvisc-One

The side effects most commonly seen in the medical study were knee pain, stiffness and swelling or fluid buildup in or around the knee. Side effects were generally mild to moderate and did not last long.

The types and frequencies of side effects were similar between the Synvisc-One and the saline control groups. No serious side effects were seen in the injected knee during the study that were related to the use of Synvisc-One.


1. Chevalier X, Jerosch J, Goupille P, et al. Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis. 2010;69(1):113-119. doi:10.1136/ard.2008.094623.

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