Get answers to your questionsabout Synvisc-One.

A A

What is Synvisc-One?

Synvisc-One is an injection that supplements the fluid in your knee to help lubricate and cushion the joint, and can provide up to six months of osteoarthritis knee pain relief.

When should I consider Synvisc-One?

Synvisc-One is for people with knee osteoarthritis who have not received enough pain relief from diet, exercise and over-the-counter pain medication. If you’ve tried these options and are still feeling knee pain, tell your doctor and ask if Synvisc-One could help.

  Still wondering if Synvisc-One could be right for you? Watch this video to find out more.

How is Synvisc-One given?

Synvisc-One is a single-dose treatment that is injected directly into your knee by a doctor, usually a specialist trained in treating knee osteoarthritis, such as an orthopaedic surgeon or rheumatologist.

Is Synvisc-One covered by insurance?

Synvisc-One is covered by Medicare and most insurance plans. If you have been denied coverage, click here.

What are the side effects of Synvisc-One?

The most common side effects are pain, swelling, heat, redness and/or fluid build-up around the knee. In a medical study less than 6% of patients experienced these side effects, which were generally mild and did not last long.

What is the procedure like?

The injection takes a few minutes and can be done in your doctor’s office. To watch a video of a real patient’s injection, click here.

Will the injection hurt?

Your doctor will likely apply a numbing agent before your Synvisc-One injection.

What happens after the injection?

It is recommended you avoid strenuous activities (for example, high-impact sports such as tennis or jogging) or prolonged weight-bearing activities for approximately 48 hours following the injection. You should consult your doctor regarding the appropriate time to resume these activities.

When will I start to feel pain relief?

Everyone responds differently, but in a medical study1 of 253 patients with knee osteoarthritis, many experienced pain relief starting one month after the injection of Synvisc-One.

How long will I experience knee pain relief?

Although all patients respond differently, your osteoarthritis knee pain relief can last up to six months.

Can I receive Synvisc-One treatment more than once?

Yes, Synvisc-One can be repeated safely. In a medical study involving 160 patients, 77 received a second injection of Synvisc-One. When your osteoarthritis knee pain returns, talk to your doctor to see if Synvisc-One is right for you.

Can both my knees be treated with Synvisc-One?

Yes. You can receive treatment in both knees at the same time or at different times. Ask your doctor what is best for you.

What is Synvisc-One made from?

The injection contains a gel-like mixture made from a substance called hyaluronan (pronounced hy-al-u-ROE-nan) that comes from chicken combs. Hyaluronan is a natural substance found in the body and is present in very high amounts in joints. The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint and is needed for the joint to work properly.

How is Synvisc-One different from SYNVISC® (hylan G-F 20)?

Synvisc-One is the same formulation as SYNVISC. The only difference is that Synvisc-One is provided with one injection, compared to the three injections required for SYNVISC. Both treatments can provide up to six months of osteoarthritis knee pain relief.


Find a Synvisc-One doctor near you.

Sign up for exercise videos and knee osteoarthritis information

email image Sign Up

See a real patient's injection with Synvisc-One

Watch Video

Print the 7 things you need to know about Synvisc-One®

Print